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aicar biochemical  (Tocris)


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    Tocris aicar biochemical
    The <t>AMPK</t> <t>activator,</t> <t>AICAR,</t> attenuates NMDA-induced cell loss in the ganglion cell layer (GCL). The number of cells in the GCL and thickness of the inner plexiform layer (IPL) were measured seven days after intravitreal injection. ( A ): Saline ( a ); NMDA (200 nmol) + vehicle ( b ); NMDA (200 nmol) + AICAR (20 nmol) ( c ); NMDA (200 nmol) + AICAR (50 nmol) ( d ). Scale bar, 30 µm. ( B ): Bar graph showing the number of cells in the GCL and thickness of the IPL. n = 5–6. ** p < 0.01; Kruskal–Wallis test.
    Aicar Biochemical, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aicar biochemical/product/Tocris
    Average 90 stars, based on 1 article reviews
    aicar biochemical - by Bioz Stars, 2026-04
    90/100 stars

    Images

    1) Product Images from "Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats"

    Article Title: Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms22094439

    The AMPK activator, AICAR, attenuates NMDA-induced cell loss in the ganglion cell layer (GCL). The number of cells in the GCL and thickness of the inner plexiform layer (IPL) were measured seven days after intravitreal injection. ( A ): Saline ( a ); NMDA (200 nmol) + vehicle ( b ); NMDA (200 nmol) + AICAR (20 nmol) ( c ); NMDA (200 nmol) + AICAR (50 nmol) ( d ). Scale bar, 30 µm. ( B ): Bar graph showing the number of cells in the GCL and thickness of the IPL. n = 5–6. ** p < 0.01; Kruskal–Wallis test.
    Figure Legend Snippet: The AMPK activator, AICAR, attenuates NMDA-induced cell loss in the ganglion cell layer (GCL). The number of cells in the GCL and thickness of the inner plexiform layer (IPL) were measured seven days after intravitreal injection. ( A ): Saline ( a ); NMDA (200 nmol) + vehicle ( b ); NMDA (200 nmol) + AICAR (20 nmol) ( c ); NMDA (200 nmol) + AICAR (50 nmol) ( d ). Scale bar, 30 µm. ( B ): Bar graph showing the number of cells in the GCL and thickness of the IPL. n = 5–6. ** p < 0.01; Kruskal–Wallis test.

    Techniques Used: Injection, Saline



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    Image Search Results


    The AMPK activator, AICAR, attenuates NMDA-induced cell loss in the ganglion cell layer (GCL). The number of cells in the GCL and thickness of the inner plexiform layer (IPL) were measured seven days after intravitreal injection. ( A ): Saline ( a ); NMDA (200 nmol) + vehicle ( b ); NMDA (200 nmol) + AICAR (20 nmol) ( c ); NMDA (200 nmol) + AICAR (50 nmol) ( d ). Scale bar, 30 µm. ( B ): Bar graph showing the number of cells in the GCL and thickness of the IPL. n = 5–6. ** p < 0.01; Kruskal–Wallis test.

    Journal: International Journal of Molecular Sciences

    Article Title: Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats

    doi: 10.3390/ijms22094439

    Figure Lengend Snippet: The AMPK activator, AICAR, attenuates NMDA-induced cell loss in the ganglion cell layer (GCL). The number of cells in the GCL and thickness of the inner plexiform layer (IPL) were measured seven days after intravitreal injection. ( A ): Saline ( a ); NMDA (200 nmol) + vehicle ( b ); NMDA (200 nmol) + AICAR (20 nmol) ( c ); NMDA (200 nmol) + AICAR (50 nmol) ( d ). Scale bar, 30 µm. ( B ): Bar graph showing the number of cells in the GCL and thickness of the IPL. n = 5–6. ** p < 0.01; Kruskal–Wallis test.

    Article Snippet: In the second series of experiments, we examined the effect of AICAR (Tocris Bioscience), an activator of AMPK, on NMDA (200 nmol)-induced retinal neuronal cell loss in the GCL.

    Techniques: Injection, Saline